Estradiol: what pharmacies actually pay
Prices below are the National Average Drug Acquisition Cost (NADAC) — the federal government's weekly survey of what pharmacies actually pay their wholesalers, as of 07/22/2026. Your pharmacy's cash price includes their markup and dispensing cost, so it will be higher — but if it's many times this number, that's a signal to shop around.
| Form & strength | Pharmacy cost | Unit | Type |
|---|---|---|---|
| ESTRADIOL 0.01% CREAM | $0.38 | per gram | Generic |
| ESTRADIOL 0.025 MG PATCH(1/WK) | $11.34 | per tablet/unit | Generic |
| ESTRADIOL 0.025 MG PATCH(2/WK) | $7.83 | per tablet/unit | Generic |
| ESTRADIOL 0.0375 MG PATCH(1/WK) | $11.42 | per tablet/unit | Generic |
| ESTRADIOL 0.0375 MG PATCH(2/WK) | $8.03 | per tablet/unit | Generic |
| ESTRADIOL 0.05 MG PATCH (1/WK) | $10.63 | per tablet/unit | Generic |
| ESTRADIOL 0.05 MG PATCH (2/WK) | $7.98 | per tablet/unit | Generic |
| ESTRADIOL 0.06 MG PATCH (1/WK) | $12.29 | per tablet/unit | Generic |
| ESTRADIOL 0.06% 1.25G GEL PUMP | $3.51 | per gram | Generic |
| ESTRADIOL 0.075 MG PATCH(1/WK) | $12.15 | per tablet/unit | Generic |
| ESTRADIOL 0.075 MG PATCH(2/WK) | $7.69 | per tablet/unit | Generic |
| ESTRADIOL 0.1 MG PATCH (1/WK) | $12.54 | per tablet/unit | Generic |
| ESTRADIOL 0.1 MG PATCH (2/WK) | $7.74 | per tablet/unit | Generic |
| ESTRADIOL 0.1% (0.25 MG) GEL PK | $1.14 | per tablet/unit | Generic |
| ESTRADIOL 0.1% (0.5 MG) GEL PKT | $1.25 | per tablet/unit | Generic |
| ESTRADIOL 0.1% (0.75 MG) GEL PK | $1.02 | per tablet/unit | Generic |
| ESTRADIOL 0.1% (1 MG) GEL PKT | $1.28 | per gram | Generic |
| ESTRADIOL 0.1% (1.25 MG) GEL PK | $1.02 | per gram | Generic |
| ESTRADIOL 0.5 MG TABLET | $0.06 | per tablet/unit | Generic |
| ESTRADIOL 1 MG TABLET | $0.06 | per tablet/unit | Generic |
| ESTRADIOL 10 MCG VAGINAL INSRT | $5.91 | per tablet/unit | Generic |
| ESTRADIOL 2 MG TABLET | $0.08 | per tablet/unit | Generic |
| ESTRADIOL VALERATE 100 MG/5 ML | $20.93 | per mL | Generic |
| ESTRADIOL VALERATE 200 MG/5 ML | $34.84 | per mL | Generic |
| ESTRADIOL VALERATE 50 MG/5 ML | $18.28 | per mL | Generic |
Rough math: a typical 30-day supply of one tablet/day equals 30× the per-unit cost.
This is pricing information, not medical advice. Talk to your doctor or pharmacist before changing any medication.
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